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1997 )and in utero administration to the human fetus(Cosmi et al. Cardone M, Porto C, Tarallo A, Vicinanza M, Rossi B, Polishchuk E, Donaudy F, Andria G,De Matteis MA, Parenti G (2008) Abnormal mannose-6-phosphate receptor traf? cking impairsrecombinant alpha-glucosidase uptake in Pompe disease ?broblasts. Patient gives her pain a 4 on a pain scale of 1–7 where 1 is no pain and 7 is excruciating pain.3. A multicenter randomized controlled clinical trial A multicenter randomized controlled clinical trial. Chemical cystitis and haematuria may develop withhigh doses given for long periods. There isreduction of GFR, proteinuria, hematuria, etc.
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